One of the things that irritates me the most in Vista is the enabled by default Full Row Selection in Explorer. To see what I'm talking about open an Explorer window in Details View and try to select files with dragging a rectangle. I googled a bit and found that there is a solution for the problem:
Under the key:
[HKCU\Software\Microsoft\Windows\CurrentVersion\Explorer\Advanced]
Create a new REG_DWORD value named FullRowSelect. Leave it's data as 0x0 and you are set.
After some more digging, I found several scripts which will automatically set and unset this key for you:
I hope this helps.